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Otorhinolaryngology News
Abreast Of  Ear, Nose & Throat / Head & Neck Advances
11 November 2005
Hello, All. You are Welcome to this week's ORL Update. I do hope you find my picks for this week exciting and useful
Biodun Olusesi, Newsletter Editor
Surgical Fibrosis & Bacteria

One area where prevention of surgical fibrosis is of immense importance to the Otolaryngologist is restenosis of external auditory canal following meatoplasty / canalplasty. Ruiz-Peraz & Tzianabos recently (Proc. Natl. Acad. Sci. USA, 10.1073/pnas.0505688102, November 7, 2005) demonstrated that the interaction of the zwitterionic polysaccharides with T cells results in modulation of surgical fibrosis in vivo and suggest a previously undescribed approach to "harnessing" T cell function to prevent inflammatory tissue disorders in humans..

 Abstract: Bacterial carbohydrates have long been considered T cell-independent antigens that primarily induce humoral immune responses. Recently, it has been demonstrated that bacterial capsules that possess a zwitterionic charge motif can activate CD4+ T cells after processing and presentation by antigen-presenting cells. Here we show that these zwitterionic polysaccharides can prevent T helper 1-mediated fibrosis by signaling for the release of IL-10 from CD4+ T cells in vivo. IL-10 production by these T cells and their ability to prevent fibrosis is controlled by the inducible costimulator (ICOS)-ICOS ligand pathway. These data demonstrate that the interaction of the zwitterionic polysaccharides with T cells results in modulation of surgical fibrosis in vivo and suggest a previously undescribed approach to "harnessing" T cell function to prevent inflammatory tissue disorders in humans.

TOP PICKS

Needed: Multicenter study on HIV & Malignancies in Nigeria...
Following a paper published by Ocheni & Aken'ova in 2004 (West Afr. J. Med. 2004 Apr-Jun, 23(2);151-5), and with an increasing number of HIV patients being diagnosed in otolaryngology clinics across Nigeria, it has become apparent that there is a need for a multicenter study on the incidence, prevalence and other variables determining the histological types and behaviors of malignancies seen in HIV+ patients...Click Here for more information

New Forum For Otolaryngologists in Africa...
A new online forum has just being created to enable Otolaryngologists in Africa share opinions, discuss cases, and keep abreast of other global events concerning the sciences and arts of otolaryngology. You are cordially invited to be a member of this new group designed to advance otolaryngology to the NEXT level. Feel free to forward this information to other Otolaryngologists known to you who might be interested in being part of this event. To view this blogsite, click Here...

Your approach to subglottic stenosis in a neonate.....
Will you or will you not carry out cricotracheal resection (CTR) for subglottic stenosis in a child weighing 10kg or less? Garabedin et al recently (Arch Otolaryngol Head Neck Surg 2005 Jun;131(6):505-8.) gave the first reported attempts at  CTR in this weight category and concluded that the result compares well with results in older children

Abstract:

OBJECTIVE: To review cricotracheal resection (CTR) in children weighing less than 10 kg. DESIGN AND SETTING: Retrospective study of 17 patients (mean follow-up, 23 months) from 3 ear, nose, and throat pediatric
centers. PATIENTS: Seventeen children (10 boys and 7 girls; mean age, 14.6
months; and mean weight, 7.6 kg) undergoing CTR from June 1995 to March
2003. MAIN OUTCOME MEASURES: Decannulation rates and endoscopies. RESULTS: The cause was congenital subglottic stenosis in 2 children (12%) and
acquired subglottic stenosis in 15 (88%). All but 1 had grade 3 or 4
stenosis. The mean hospitalization duration was 34 days. Single-stage CTR
was performed in 11 children (65%), with peroperative decannulation in 7.
Extubation of these patients occurred between days 3 and 9. Decannulation
of the other 6 patients was performed after a median of 15 days. Sixteen
(94%) of the 17 children were decannulated. Four patients required
additional carbon dioxide laser treatment for subsequent glottic or
subglottic edema or granulomas, but no reintubation was necessary. One
child could not be decannulated because of bronchopulmonary disease, and
subglottic stenosis recurred. Long-term tracheotomy was avoided in all
other patients. Another child died of cardiac disease. All other patients
remained free of significant subglottic stenosis at follow-up.
CONCLUSIONS: Cricotracheal resection in small children weighing less than
10 kg was a safe and effective procedure for severe subglottic stenosis.
To our knowledge, this is the first reported attempt of CTR in this weight
category, providing results comparable to those published in older
children.

 

Case Review
 
CLINICAL PHOTO OF THE WEEK

30-year old female with long-standing history of right muco-purulent Otorrhoea since childhood. No previous ear surgery, but had I&D of post-auricular swelling done by a GP at about age 10 years. O/E findings include right complete LMN facial palsy, large mastoid cavity with mucopurulent Otorrhoea and the finding seen on this picture

What is the diagnosis?

Parting Shot...
If you have an interesting case to discuss or share with other Otolaryngologists all over Africa, feel free to email me or at best go to otolaryngology in Africa blogsite and post your case

Till Next Week,

Biodun

 

 

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© Copyright Dr 'Biodun Olusesi,  2005

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