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Abreast Of Ear, Nose &
Throat / Head & Neck Advances
7 January, 2006
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Hello, All. Welcome to 2006
and
to this week's ORL Update. I do hope you find my picks
for this week exciting and useful |
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Biodun Olusesi,
Newsletter Editor |
Nitric Oxide and Otitis Media with Effusion.......
Since the 1985
review paper published by
Bernstein,
stressing the need for molecular approach to
understanding middle ear inflammation in OME, Most
of the publications on this subject have been
largely clinical. Hisamatsu K et al recently (Ann
Otol Rhinol Laryngol. 2005 Oct;114(10):804-8.)
took up the challenge of Bernstein by attempting
to link up the ubiquitous molecule - Nitric Oxide
- superoxide system to mucosal cell injury in OME.
Abstract: OBJECTIVES: Our purpose was
to investigate mucosal cell injury due to the
nitric oxide (NO)-superoxide system in otitis
media with effusion. METHODS: We determined the
levels of nitrotyrosine (NT) and NO and the
activities of superoxide dismutase (SOD) and
lactic dehydrogenase (LDH) in 90 middle ear fluid
samples. RESULTS: The NT concentration was
significantly higher in group A (<16 years old)
than in group C (>50 years old; p < .05), and
significantly higher in the acute group than in
the chronic group (p < .05). The NO concentration
did not show a significant difference among the
groups. The activity of SOD showed significant
correlations with the concentrations of NT and NO
and with LDH activity (p< .05). The LDH activity
was significantly greater in group A than in group
C (p < .05). CONCLUSIONS: Our results indicate
involvement of the NO-superoxide system in the
pathogenesis of otitis media with effusion,
showing evidence of protein and/or cell injury in
the middle ear.
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TOP PICKS
Reccurent
Tonsillitis and Carditis...?
A not-too-recent study from Turkey (Pac A et al, Int J
Pediatr Otorhinolaryngol. 2005 Apr;69(4):527-32.)
compared cardiac function in children with or without
adenotonsillar hypertrophy and concluded that a
correlation exist between adenotonsillar hypertrophy and
possible silent carditis following frequent tonsillitis
Abstract: OBJECTIVE: Comparison of cardiac
function in children with and without adenotonsillar
hypertrophy. METHODS: We examined 28 pediatric patients
with adenotonsillar hypertrophy mean aged 7.3+/-2.9
years comprised of 14 females and 14 males (group I).
The control group were chosen from 35 healthy sex and
age matched children mean aged 7.37+/-2.7 years (group
II). Both groups were examined by an
otorhinolaryngologist and adenotonsillar hypertrophy was
diagnosed with nasal endoscopic method or lateral neck
X-ray. All the patients in group I underwent
adenotonsillectomy. Cardiologic and echocardiographic
examinations were performed in both groups.
Echocardiographic examination was done twice in group I
(preoperative and postoperative first month) however in
group II only once. Preoperative findings of group I
compared with the findings of group II. Preoperative and
postoperative echocardiographic findings were also
compared within group I. The chi-square test and the
independent paired-sample t-test were used for
statistical analysis. RESULTS: The tricuspid
end-diastolic time was the only significant difference
in echocardiographic findings between the two groups
(104.8+/-28.8 ms versus for 86.4+/-17.32 ms p<0.05).
There was no statistical difference between preoperative
and postoperative echocardiographic findings in group I.
Brady-tachyarrhythmia was detected on
electrocardiography - performed with 24h ambulatory
electrocardiography - in one patient. To our surprise,
in group I five patients had cardiac valve damage:
mitral and/or aortic valve insufficiency. These findings
were interpreted as silent carditis.CONCLUSION: There
was no significant difference in right ventricular
function between the children with and without
adenotonsillar hypertrophy.Whereas, there was shortening
of tricuspid end-diastolic time in group I.However, five
patients having adenotonsillar hypertrophy developed a
cardiac dysfunction which was not observed in the
control group.Therefore, we assumed a correlation
between adenotonsillar hypertrophy and possible silent
carditis following frequent tonsillitis.
Coming Events of Importance to Otolaryngologists in
Africa...
- Annual West Africa
College of Surgeons Conference, Accra, Ghana, Feb
2006.
-
Association of Paediatric Otolaryngologists of
India 12th Annual Conference and CME in Paediatric
Otolaryngology
February 25-26, 2006; New Delhi, India
-
8th International Otology Course of the Jean Causse
Ear Clinic
June 22-24, 2006; Béziers, France
-
110th American Academy of ORL,Head & Neck Surgery
Annual Meeting & OTO EXPO
September 17-20, 2006;
Toronto, Canada.
-
42nd South African ENT Congress joint meeting with
the British Association of Otolaryngology - Head &
Neck Surgery
October 29-November 1, 2006;
Cape Town, South Africa.
For more courses and workshops and conferences....Click
Here
Paediatric Cholesteatoma - What Approach Is Best.....?
Schraff SA et al in a retrospective review on best
surgical approach to paediatric cholesteatoma reviewed
262 cases and concluded that the management needs to be
individualized.
Abstract:
OBJECTIVES: The optimal treatment for pediatric
cholesteatoma is controversial. Management decisions
including intact canal wall versus open cavity
techniques, second look procedures and staging ossicular
reconstruction continue to be debated. In an attempt to
clarify this issue we conducted an 11-year retrospective
analysis of our experience with cholesteatoma presenting
in our pediatric population. STUDY DESIGN: Retrospective
review of children undergoing surgical intervention for
cholesteatoma at a tertiary care pediatric hospital
between 1 July 1992 and 1 July 2003 by the senior
author. METHODS: Comparison of recurrence rates in
intact canal wall (ICW) versus canal wall down (CWD)
procedures; with analysis of second-look procedures,
ossicular chain reconstruction (OCR) and hearing results
in the management of pediatric cholesteatoma. RESULTS:
Two hundred and sixty-two children with 278 cases of
cholesteatoma underwent surgical resection. Of these
children, 221 were managed via an ICW approach while the
remaining 57 underwent a CWD procedure. The overall
recurrence rate in this series was 16%, with 17% in the
ICW group and 12% in the CWD group. OCR was performed in
97% of the ICW cases at time of second-look procedure,
with 75% undergoing reconstruction with partial
ossicular reconstruction prosthesis. The average
air-bone gap improvement in these patients was 10.8dB,
with an average hearing improvement of total ossicular
reconstruction of 5.8dB. The average hearing improvement
in the CWD group, all managed with cartilage
interposition grafts, was 3.7dB. CONCLUSIONS: Management
of pediatric cholesteatoma requires a highly
individualized approach that takes into account
anatomic, clinical and social factors to determine the
most successful surgical treatment paradigm.
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CLINICAL PHOTO OF THE WEEK |
A
66-year old male presented with recurrent painful
swelling right upper neck of 2 months duration.
The painful swelling was worse during feeding. He
had no dental or pharyngo-laryngeal symptoms. Examination revealed the feature
(white arrow) on this picture. CT-Scan showed a
well encapsulated mass with solitary extra
capsular node about 0.75 cm diameter.
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What is the diagnosis?
- Parting Shot...
If you have an interesting
case to discuss or share with other Otolaryngologists
all over Africa, feel free to email
Me or at best go to
otolaryngology in Africa blogsite
and post your case
- Also, if you are among those who requested for a copy
of DODA at the last ORLSON Meeting @ Port Harcourt,
please take time to view the
DODA - FAQ page,
and expect your copy anytime now. The program is being
shipped to you.
- An online video demonstration of doda is available
at
http://www.otolaryngologyinafrica.net/doda_video.htm
This
video takes about 30 - 45 minutes to fully load on a
broad band network the first time, but once fully
loaded could be viewed over and over again
Till Next Week,
Biodun
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© Copyright Dr 'Biodun
Olusesi,
2005 - 2006 |