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Abreast Of Ear, Nose &
Throat / Head & Neck Advances
22 January, 2006
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Hello, All. Welcome
to this week's ORL Update. I do hope you find my picks
for this week exciting and useful |
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EDITOR'S CHOICE
Biodun Olusesi,
Newsletter Editor |
Silence and Auditory Activity.......
Ever wonder what happens to the auditory cortex
in conditions of depressed reticular activation
states like hypnosis, delirium, psychosis, drug
intoxication, or drowsiness? Well a new functional
MRI study by Hunter et al (PNAS
| January 3, 2006 | vol. 103 | no. 1 |
189-194
) designed to address this question concluded that the
anterior cingulate cortex modulates the activity
of primary and associated auditory cortices
resulting in foci of spontaneous activities during
silence.
Abstract: That
auditory hallucinations are
voices heard in the absence of external
stimuli implies the existence of endogenous neural
activity within the
auditory cortex responsible for
their perception. Further,
auditory hallucinations occur
across a range of healthy and disease
states that include reduced arousal, hypnosis,
drug intoxication, delirium, and
psychosis. This suggests that, even in
health, the
auditory cortex has a
propensity to spontaneously "activate"
during silence. Here we report the findings of a
functional MRI study, designed to examine
baseline activity in speech-sensitive
auditory regions. During
silence, we show that functionally
defined speech-sensitive
auditory cortex is
characterized by intermittent episodes of
significantly increased activity in a
large proportion (in some cases >30%) of its
volume. Bilateral increases in activity are
associated with foci of spontaneous
activation in the left primary and association
auditory cortices and anterior
cingulate cortex. We suggest that,
within
auditory regions, endogenous
activity is modulated by anterior
cingulate cortex, resulting in spontaneous
activation during silence. Hence, an
aspect of the brain's "default mode"
resembles a (preprepared) substrate for the
development of
auditory
hallucinations. These observations may help
explain why such hallucinations are
ubiquitous.
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TOP PICKS
The
Next Big Thing After laser...?
After almost half a century since discovery of laser,
researchers at Lawrence Livermore Laboratory and
the MIT, both in the USA have just figured out how to
produce coherent optical radiation that is distinct from
lasers and free electron lasers.
Extracts: Applications
from this research are numerous, but the most immediate
result may be a new
diagnostic
tool
to determine the properties of shock waves, said Evan
Reed, an E.O. Lawrence postdoctoral fellow at Lawrence
Livermore and lead author of a paper that appears in the
Jan. 13 edition of Physical Review Letters.
Through a series of theoretical calculations and
experimental simulations,
scientists generated a
mechanical shock wave inside a dielectric crystalline
material, in this case kitchen salt (NaCl). One might
expect to see only incoherent photons and sparks from
the shocked crystal.
But what they found was so much more. Weak yet
measurable coherent light was seen emerging from the
crystal. The emission frequencies are determined by the
shock speed and the lattice make-up of the crystal.
The team found that measurable coherent light can be
observed emerging from the crystal in the range of 1 to
100 terahertz (THz).. ..
For more of this story, click
HERE
Coming Events of Importance to Otolaryngologists in
Africa...
-
7th
International Congress of the Egyptian ORL Society
25
- 27 Jan 2006. Meridien Pyramids Hotel , Haram ,
Giza. Egypt. For More information, Click
HERE
-
BRITISH
ACADEMIC CONFERENCE IN OTOLARYNGOLOGY - Humanitarian
Award, 2006. For Details
click
HERE
- Annual West Africa
College of Surgeons Conference, Accra, Ghana, Feb
2006.
-
Association of Paediatric Otolaryngologists of
India 12th Annual Conference and CME in Paediatric
Otolaryngology
February 25-26, 2006; New Delhi, India
-
8th International Otology Course of the Jean Causse
Ear Clinic
June 22-24, 2006; Béziers, France
-
110th American Academy of ORL,Head & Neck Surgery
Annual Meeting & OTO EXPO
September 17-20, 2006;
Toronto, Canada.
-
42nd South African ENT Congress joint meeting with
the British Association of Otolaryngology - Head &
Neck Surgery
October 29-November 1, 2006;
Cape Town, South Africa.
For more Worldwide otolaryngological events and conferences....Click
Here
Looking Deeper into Subglottic stenosis.....?
To examine the cellular process underlying the
difficult-to-treat subglottic stenosis, a recent animal
study from Pittsburg (Sandulache
VC et al, Arch Otolaryngol Head Neck Surg. 2005
Dec;131(12):1090-6.)demonstrated successful
transplantation of exogenous fibroblasts from the dermis
and subglottic mucosa into the injured subglottis of
experimental rabbits.
Abstract:
OBJECTIVE: Because subglottic stenosis (SGS) represents
one of the most challenging pathologies confronting the
pediatric otolaryngologist, our laboratory is
investigating the role fibroblasts play in mucosal scar
formation in the course of SGS development. Our
objective is to establish cell transplantation into the
subglottic mucosal wound bed as a viable tool for
examining the cellular processes that underlie the
development of SGS. DESIGN: A series of 2 animal
experiments, with animals assigned to a control,
vehicle-only, or cell-treated group. SETTING: John G.
Rangos Sr Research Center, Children's Hospital of
Pittsburgh, Pittsburgh, Pa. SUBJECTS: Twenty-six New
Zealand white rabbits. This animal model has been well
established in the study of SGS formation.
INTERVENTIONS: Fluorescently labeled exogenous
fibroblasts were transplanted into the injured
subglottis of the rabbits. RESULTS: Exogenous
fibroblasts derived from fetal and adult dermis and
subglottic mucosa were successfully transplanted into
the injured subglottic mucosa of adult rabbits.
Transplanted fibroblasts survived into the latter stages
of wound healing (at 14 and 21 days) and appeared to be
associated with a mild inflammatory cell influx and
active remodeling of the mucosal wound bed. CONCLUSION:
Cell transplantation is a viable tool for the study of
fibroblast activity in the mucosal wound bed.
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CLINICAL PHOTOGRAPH OF THE WEEK |
An
11-year old male presented with 3-week history of
persistent fever, nasal obstruction with mouth
breathing, and swelling of the nose.
The symptoms were preceded by history of blunt
injury to the nose while trying to separate his
classmates who were fighting. There was little
response to antibiotic therapy given by the GP
before referral. Examination revealed the
nasal feature displayed on this radiograph.
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What is the diagnosis?
- Parting Shot...
If you have an interesting
case to discuss or share with other Otolaryngologists
all over Africa, feel free to email
Me or at best go to
otolaryngology in Africa blogsite
and post your case
- Also, if you are among those who requested for a copy
of DODA at the last ORLSON Meeting @ Port Harcourt,
please take time to view the
DODA - FAQ page,
and expect your copy anytime now. The program is being
shipped to you.
- An online video demonstration of doda is available
at
http://www.otolaryngologyinafrica.net/doda_video.htm
This
video takes about 30 - 45 minutes to fully load on a
broad band network the first time, but once fully
loaded could be viewed over and over again
- It appears as if the website of ORLSON -
http://www.orlson.org/ is no longer active
or visible on the web! Please For a list of active web
sites of otolaryngological societies in Africa, click
HERE
- If you have anything you want to communicate with
other Otolaryngologists - news, request, etc, feel
free to email your communication to
orl-mailer@
otolaryngologyinafrica.net.
Your request will appear in member's page soon to be
created.
- Reviewers wanted for otolaryngology news journals
watch page. If you are an Otolaryngologist in Africa
and will like to be our journal reviewer, please feel
free to email
orl-mailer@otolaryngologyinafrica.net
Till Next Week,
Biodun
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© Copyright Dr 'Biodun
Olusesi,
2005 - 2006 |