Text Box: Newsletter
Abreast Of  Ear, Nose & Throat / Head & Neck Advances
26, February,  2006
 
Hello, All. Welcome to this week's ORL Update. I do hope you find my picks for this week useful and informative
 
Biodun Olusesi, Newsletter Editor
Auditory Function in COPD.......?
It is a known fact that chronic obstructive pulmonary disease (COPD) is associated with arterial hypoxemia and hypercapnia. It is also an acceptable fact that the transduction mechanism in the inner ear is highly dependent upon cochlear oxygen supply. The synergy of these two medical facts formed the basis of a recent paper from Egypt by El-Kady et al (Hearing Research
Volume 212, Issues 1-2 , February 2006, Pages 109-116
) which concluded among others that Chronic hypoxemia can affect human auditory function, namely at the levels of the outer hair cells, inner hair cells, cochlear nerve, and the auditory brainstem and  that the outer hair cells appeared to be the most vulnerable to moderate chronic hypoxemia.The paper also asserted that the evoked otoacoustic emissions thus can be considered the most sensitive test to measure the auditory function in patients with chronic obstructive pulmonary diseases

Abstract: This study was designed to measure auditory function in patients with chronic obstructive pulmonary diseases (COPDs) who generally suffer from chronic hypoxemia. Control and COPD subject groups received a battery of tests to assess overall hearing sensitivity and peripheral (end-organ and eighth-nerve) and brain-stem auditory function, as well as blood-gas analysis. Results showed a statistically significant difference for all audiological measures between the control group and a COPD subgroup – the presumptive hypoxic subjects (partial oxygen tensions, PO2, <75 mm Hg). Correlation analyses of results from all subjects (regardless of PO2) also revealed significant covariance with PO2 for overall, RMS, amplitude of click-evoked otoacoustic emissions (RA), hearing threshold level, and auditory brain-stem response (ABR, I-V inter-peak latency). χ2 or Fisher’s exact tests were statistically significant for frequencies of cases classified according to a criterion PO2 of 70 mm Hg (putative critical O2 for completely normal auditory function) and either hearing thresholds falling below or RA values above 1.5 standard deviations of the control-group means, respectively. However, χ2 was not significant for a comparable criterion of ABR I-V IPL. In general, clinically significant hearing loss was uncommon in COPD patients, and the observed effects represented relatively small changes in the auditory measures examined. Still, overall, changes were in the direction of poorer function, and these results suggest physiologically significant impact of chronic hypoxemia and the need for further study to evaluate thoroughly this medical condition as a potential risk factor for audio-vestibular dysfunction.
 
TOP PICKS

Taste Disturbance After Tonsillectomy and microlaryngoscopy...?
A not-too-recent Japanese paper (Tomofuji et al; Auris Nasus Larynx 32 (2005) 381–386 )explored taste disturbance after tonsillectomy and laryngeal microsurgery and observed taste disturbance in as much as 25% of post tonsillectomy subject, and 2% of those who had laryngomicrosurgery. Reason adduced for the taste disturbance include injury to chorda tympani and / or glossopharyngeal nerve, and drug-induced (especially zinc-chelating analgesics). The author highlighted the likely of patients confusing the symptom of tongue numbness with taste disturbance.

Abstract: Objective: To investigate the incidence of taste disturbance after tonsillectomy and laryngomicrosurgery. Study design: A prospective study. Methods: Thirty-five consecutive patients underwent tonsillectomy with electric coagulator at Kanebo Memorial Hospital from September 2002 to May 2004. Another 35 consecutive patients underwent laryngomicrosurgery in a routine way during the same period. Both procedures were performed by two experienced doctors. The postoperative taste function was evaluated with questionnaire, electrogustometry (EGM), and serum levels of Zn, Cu and Fe. Results: After tonsillectomy, 3/35 patients (8.6%) complained of taste disturbance, due to the pressure on the tongue in two, and Zn deficiency after lack of intake in one. All three patients recovered taste within 1.5 months. None of our patients had taste disturbance due to surgical insult of the lingual branch of the glossopharyngeal nerve. After laryngomicrosurgery, only one patient (2.9%) complained of taste disturbance with elevation of the EGM threshold that resulted from the pressure on the tongue. In addition, abnormal sensation in the tongue occurred in 9 cases (25.7%) after tonsillectomy and in 2 cases (5.7%) after laryngomicrosurgery, and feeling of thirst occurred in 12 cases (34.3%) and in 8 cases (22.9%), respectively. Conclusion: Taste disturbance occurs in few cases when experienced surgeons perform tonsillectomy or laryngomicrosurgery. However, it is recommended to inform the patients of the potential postoperative complications such as taste disturbance and abnormal sensation of the tongue.

A follow-up publication from New York (Tessema B. et al; Ann Otol Rhinol Laryngol. 2006 Jan;115(1):18-22) also observed direct relationship between  tongue dysgeusia / paraesthesia and duration of microlaryngoscopy and attributed these to lingual nerve injury.


Coming Events of Importance to Otolaryngologists in Africa...
 

  1. 8th International Otology Course of the Jean Causse Ear Clinic
    June 22-24, 2006; Béziers, France
  2. 110th American Academy of ORL,Head & Neck Surgery Annual Meeting & OTO EXPO
    September 17-20, 2006;
    Toronto, Canada.
  3. 42nd South African ENT Congress joint meeting with the British Association of Otolaryngology - Head & Neck Surgery
    October 29-November 1, 2006;
    Cape Town, South Africa.

         For more Worldwide otolaryngological events and conferences....Click Here


Another Stem Cell Research breakthrough for SNHL.....?       

An Australian study (Michael S. Hildebrad et al; JARO - Journal of the Association for Research in Otolaryngology , 2005 Volume 6, Number 4, Pages: 341 - 354 ) examined the issue of embryonic stem cells survival following introduction into the inner ear and reported that partially-differentiated ES cells could survive in the scala media of mammalian cochlea

Abstract  The low regenerative capacity of the hair cells of the mammalian inner ear is a major obstacle for functional recovery following sensorineural hearing loss. A potential treatment is to replace damaged tissue by transplantation of stem cells. To test this approach, undifferentiated and partially differentiated mouse embryonic stem (ES) cells were delivered into the scala media of the deafened guinea pig cochlea. Transplanted cells survived in the scala media for a postoperative period of at least nine weeks, evidenced by histochemical and direct fluorescent detection of enhanced green fluorescent protein (EGFP). Transplanted cells were discovered near the spiral ligament and stria vascularis in the endolymph fluid of the scala media. In some cases, cells were observed close to the damaged organ of Corti structure. There was no evidence of significant immunological rejection of the implanted ES cells despite the absence of immunosuppression. Our surgical approach allowed efficient delivery of ES cells to the scala media while preserving the delicate structures of the cochlea. This is the first report of the survival of partially differentiated ES cells in the scala media of the mammalian cochlea, and it provides support for the potential of cell-based therapies for sensorineural hearing impairment.

 

 
Case Review
 
CLINICAL PHOTO OF THE WEEK

A 55-year old male complained of 3 weeks history of right aural fullness, otalgia and otorrhoea followed by persistent post-aural pain. He had initial antibiotic and analgesics therapy before presentation with resolution of otorrhoea. Examination revealed gross post-aural indurations on the ipsilateral side, with the appearance shown on the picture noted 2nd day after presentation. Otoscopy was not  remarkable at presentation, and mastoid x-ray revealed clouding of ipsilateral air cells.

 

What is the diagnosis?

  • Parting Shot...
    If you have an interesting case to discuss or share with other Otolaryngologists all over Africa, feel free to email Me or at best go to otolaryngology in Africa blogsite and post your case
  • Also, if you are among those who requested for a copy of DODA at the last ORLSON Meeting @ Port Harcourt, please take time to view the DODA - FAQ page, you should have received your copy by now. If you have difficulty on using the program, please text +2348032472069.
  • An online video demonstration of doda is available at http://www.otolaryngologyinafrica.net/doda_video.htm  This video takes about 30 - 45 minutes to fully load on a broad band network the first time, but once fully loaded could be viewed over and over again
  • If you have anything you want to communicate with other Otolaryngologists - news, request, etc, feel free to email your communication to orl-mailer@ otolaryngologyinafrica.net. Your request will appear in member's page soon to be created.
  • Reviewers wanted for otolaryngology news journals watch page. If you are an Otolaryngologist in Africa and will like to be our journal reviewer, please feel free to email orl-mailer@otolaryngologyinafrica.net

Till Next Week,

Biodun


 

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