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Abreast Of Ear, Nose &
Throat / Head & Neck Advances
26, February, 2006
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Hello, All. Welcome
to this week's ORL Update. I do hope you find
my picks for this week useful and informative |
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Biodun Olusesi,
Newsletter Editor |
Auditory Function in COPD.......?
It is a known fact
that chronic obstructive pulmonary disease (COPD)
is associated with arterial hypoxemia and
hypercapnia. It is also an acceptable fact that
the transduction mechanism in the inner ear is
highly dependent upon cochlear oxygen supply. The
synergy of these two medical facts formed the
basis of a recent paper from Egypt by El-Kady
et al (Hearing
Research
Volume 212, Issues 1-2 , February 2006, Pages
109-116 )
which concluded among others that Chronic
hypoxemia can affect human auditory function,
namely at the levels of the outer hair cells,
inner hair cells, cochlear nerve, and the auditory
brainstem and that the outer hair cells
appeared to be the most vulnerable to moderate
chronic hypoxemia.The paper also asserted that the
evoked otoacoustic emissions thus can be
considered the most sensitive test to measure the
auditory function in patients with chronic
obstructive pulmonary diseases
Abstract: This study was designed to
measure auditory function in patients with chronic
obstructive pulmonary diseases (COPDs) who
generally suffer from chronic hypoxemia. Control
and COPD subject groups received a battery of
tests to assess overall hearing sensitivity and
peripheral (end-organ and eighth-nerve) and
brain-stem auditory function, as well as blood-gas
analysis. Results showed a statistically
significant difference for all audiological
measures between the control group and a COPD
subgroup – the presumptive hypoxic subjects
(partial oxygen tensions, PO2,
<75 mm Hg). Correlation analyses of results from
all subjects (regardless of PO2)
also revealed significant covariance with PO2
for overall, RMS, amplitude of click-evoked
otoacoustic emissions (RA), hearing threshold
level, and auditory brain-stem response (ABR, I-V
inter-peak latency). χ2 or
Fisher’s exact tests were statistically
significant for frequencies of cases classified
according to a criterion PO2 of
70 mm Hg (putative critical O2 for
completely normal auditory function) and either
hearing thresholds falling below or RA values
above 1.5 standard deviations of the control-group
means, respectively. However, χ2
was not significant for a comparable criterion of
ABR I-V IPL. In general, clinically significant
hearing loss was uncommon in COPD patients, and
the observed effects represented relatively small
changes in the auditory measures examined. Still,
overall, changes were in the direction of poorer
function, and these results suggest
physiologically significant impact of chronic
hypoxemia and the need for further study to
evaluate thoroughly this medical condition as a
potential risk factor for audio-vestibular
dysfunction.
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TOP PICKS
Taste
Disturbance After Tonsillectomy and
microlaryngoscopy...?
A not-too-recent Japanese paper (Tomofuji et al;
Auris Nasus Larynx 32
(2005) 381–386
)explored taste disturbance after tonsillectomy
and laryngeal microsurgery and observed taste
disturbance in as much as 25% of post tonsillectomy
subject, and 2% of those who had laryngomicrosurgery.
Reason adduced for the taste disturbance include injury
to chorda tympani and / or glossopharyngeal nerve, and
drug-induced (especially zinc-chelating analgesics). The
author highlighted the likely of patients confusing the
symptom of tongue numbness with taste disturbance.
Abstract:
Objective: To investigate the incidence of taste
disturbance after tonsillectomy and laryngomicrosurgery.
Study design: A prospective study. Methods: Thirty-five
consecutive patients underwent tonsillectomy with
electric coagulator at Kanebo Memorial Hospital from
September 2002 to May 2004. Another 35 consecutive
patients underwent laryngomicrosurgery in a routine way
during the same period. Both procedures were performed
by two experienced doctors. The postoperative taste
function was evaluated with questionnaire,
electrogustometry (EGM), and serum levels of Zn, Cu and
Fe. Results: After tonsillectomy, 3/35 patients (8.6%)
complained of taste disturbance, due to the pressure on
the tongue in two, and Zn deficiency after lack of
intake in one. All three patients recovered taste within
1.5 months. None of our patients had taste disturbance
due to surgical insult of the lingual branch of the
glossopharyngeal nerve. After laryngomicrosurgery, only
one patient (2.9%) complained of taste disturbance with
elevation of the EGM threshold that resulted from the
pressure on the tongue. In addition, abnormal sensation
in the tongue occurred in 9 cases (25.7%) after
tonsillectomy and in 2 cases (5.7%) after
laryngomicrosurgery, and feeling of thirst occurred in
12 cases (34.3%) and in 8 cases (22.9%), respectively.
Conclusion: Taste disturbance occurs in few cases when
experienced surgeons perform tonsillectomy or
laryngomicrosurgery. However, it is recommended to
inform the patients of the potential postoperative
complications such as taste disturbance and abnormal
sensation of the tongue.
A follow-up publication from New
York (Tessema B. et al;
Ann Otol Rhinol
Laryngol. 2006 Jan;115(1):18-22) also
observed direct relationship between tongue
dysgeusia / paraesthesia and duration of
microlaryngoscopy and attributed these to lingual nerve
injury.
Coming Events of Importance to Otolaryngologists in
Africa...
-
8th International Otology Course of the Jean Causse
Ear Clinic
June 22-24, 2006; Béziers, France
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110th American Academy of ORL,Head & Neck Surgery
Annual Meeting & OTO EXPO
September 17-20, 2006;
Toronto, Canada.
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42nd South African ENT Congress joint meeting with
the British Association of Otolaryngology - Head &
Neck Surgery
October 29-November 1, 2006;
Cape Town, South Africa.
For more Worldwide otolaryngological events and conferences....Click
Here
Another Stem Cell Research breakthrough for
SNHL.....?
An Australian study (Michael S. Hildebrad et al;
JARO - Journal of the Association for Research in
Otolaryngology , 2005 Volume 6, Number 4,
Pages: 341 - 354 )
examined the issue of embryonic stem cells survival
following introduction into the inner ear and reported
that partially-differentiated ES cells could survive in
the scala media of mammalian cochlea
Abstract The
low regenerative capacity of the hair cells of the
mammalian inner ear is a major obstacle for functional
recovery following sensorineural hearing loss. A
potential treatment is to replace damaged tissue by
transplantation of stem cells. To test this approach,
undifferentiated and partially differentiated mouse
embryonic stem (ES) cells were delivered into the scala
media of the deafened guinea pig cochlea. Transplanted
cells survived in the scala media for a postoperative
period of at least nine weeks, evidenced by
histochemical and direct fluorescent detection of
enhanced green fluorescent protein (EGFP). Transplanted
cells were discovered near the spiral ligament and stria
vascularis in the endolymph fluid of the scala media. In
some cases, cells were observed close to the damaged
organ of Corti structure. There was no evidence of
significant immunological rejection of the implanted ES
cells despite the absence of immunosuppression. Our
surgical approach allowed efficient delivery of ES cells
to the scala media while preserving the delicate
structures of the cochlea. This is the first report of
the survival of partially differentiated ES cells in the
scala media of the mammalian cochlea, and it provides
support for the potential of cell-based therapies for
sensorineural hearing impairment.
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CLINICAL PHOTO OF THE WEEK |
A
55-year old male complained of 3 weeks history of
right aural fullness, otalgia and otorrhoea
followed by persistent post-aural pain. He had
initial antibiotic and analgesics therapy before
presentation with resolution of otorrhoea.
Examination revealed gross post-aural indurations
on the ipsilateral side, with the appearance shown
on the picture noted 2nd day after presentation. Otoscopy
was not remarkable at presentation, and
mastoid x-ray revealed clouding of ipsilateral air
cells.
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What is the diagnosis?
- Parting Shot...
If you have an interesting
case to discuss or share with other Otolaryngologists
all over Africa, feel free to email
Me or at best go to
otolaryngology in Africa blogsite
and post your case
- Also, if you are among those who requested for a copy
of DODA at the last ORLSON Meeting @ Port Harcourt,
please take time to view the
DODA - FAQ page,
you should have received your copy by now. If you have
difficulty on using the program, please text
+2348032472069.
- An online video demonstration of doda is available
at
http://www.otolaryngologyinafrica.net/doda_video.htm
This
video takes about 30 - 45 minutes to fully load on a
broad band network the first time, but once fully
loaded could be viewed over and over again
- If you have anything you want to communicate with
other Otolaryngologists - news, request, etc, feel
free to email your communication to
orl-mailer@
otolaryngologyinafrica.net.
Your request will appear in member's page soon to be
created.
- Reviewers wanted for otolaryngology news journals
watch page. If you are an Otolaryngologist in Africa
and will like to be our journal reviewer, please feel
free to email
orl-mailer@otolaryngologyinafrica.net
Till Next Week,
Biodun
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© Copyright Dr 'Biodun
Olusesi,
2005 - 2006 |