Text Box: Abreast of Ear, Nose, Throat, Head & Neck Advances

Text Box: It is well known that glucocorticoids protect against outer hair cell (OHCs) injury resulting from aminoglycoside ototoxicity and acoustic injury. The mechanism of such protection has never been clearly explained. A recent Japanese study involving albino guinea pigs ( Tabuchi et al, Laryngoscope, Volume 116(4), April 2006, pp 627-629) examined the effects of glucocorticoids on the functional recovery of OHCs after transient cochlear ischemia by analyzing DPOAE and observed that methylprednisolone and prednisolone significantly improved the DPOAE level at 60 minutes after the onset of reperfusion  Abstract:  Objective: This animal study aimed to investigate effects of glucocorticoids on the functional recovery of outer hair cells (OHCs) after transient ischemia. Methods: Distortion-product otoacoustic emission (DPOAE) was examined before, during, and after transient cochlear ischemia of 30 minutes using albino guinea pigs. Results: DPOAE decreased to noise level during ischemia. On recirculation, DPOAE initially recovered with time until 20 minutes after the onset of reperfusion, but thereafter, the DPOAE level gradually decreased toward the noise level in the control animals. Prednisolone and methylprednisolone significantly improved the DPOAE level 60 minutes after the onset of reperfusion. Conclusions: The present findings suggest that glucocorticoids possess protective effects against ischemia–reperfusion injury of OHCs.

Text Box: Editor's Choice: Steroid & Cochlear Reperfusion Injury Text Box: Day Case UPPP...?

Text Box: Volume 3, No. 4 Text Box:   Hathaway & Johnson (Otolaryngology - Head and Neck Surgery Volume 134, Issue 4 , April 2006, Pages 542-544 ) carried out a retrospective review with EBM rating of C-4,   of 110 patients with UPPP and concluded managed at Pittsburg and concluded that UPPP is safe as a day case procedure Abstract: Objective:Determine the admission rate and characterize the complications in uvulopalatopharyngoplasty (UPPP) patients scheduled to have outpatient surgery. Study design and setting:Retrospective review of patients undergoing UPPP between 2000 and 2004 in a tertiary care setting. Results: UPPP alone or in conjunction with tonsillectomy, septoplasty, or supraglottoplasty was carried out in 110 patients. Average preoperative respiratory disturbance index (RDI) was 35. Admission was required in 20 (18%) patients whereas 90 (82%) were discharged on the day of surgery. Admission due to desaturation was noted in 3 (3%) patients. The most common reasons for admission included pain and nausea. There were no major complications. Conclusions: Careful preoperative selection of patients should permit many patients to undergo UPPP as outpatient surgery. Factors requiring admission may be assessed in the early postoperative period. The rate of respiratory events requiring postoperative admission after UPPP is low. Significance: UPPP can be carried out safely on an outpatient basis.   Text Box: April 27, 2006 Text Box: Otorhinolaryngology news

Text Box:     Links & Hyperlinks >> Text Box: Top Picks

Text Box:  30bP deletion EBV-derived  LMP-1 & NPC...?

Text Box: 1. 8th International Otology Course of the Jean Causse Ear Clinic June 22-24, 2006; Béziers, France 2. 110th American Academy of ORL,Head & Neck Surgery Annual Meeting & OTO EXPO, September 17-20, 2006; Toronto, Canada. 3. 42nd South African ENT Congress joint meeting with the British Association of Otolaryngology - Head & Neck Surgery, October 29-November 1, 2006; Cape Town, South Africa.              For more Worldwide otolaryngological events and conferences....Click Here

Text Box: Coming Events of Importance to Otolaryngologists in Africa...

Text Box: What is the diagnosis ?

Text Box: · Reviewers wanted for otolaryngology news journal's watch page. If you are an Otolaryngologist in Africa and will like to be our journal reviewer, please feel free to email orl-mailer@otolaryngologyinafrica.net · DODA 2006, capable of advanced hearing measure, and also paediatric hearing assessment is being developed. If you requested for and got a free copy of DODA, you may also look out for this latest version dubbed DODA-i, as well as for an additional page on outcome of hearing assessment using DODA.  Courtesy of NEJM, you house office / junior resident might benefit from this...Video in clinical Medicine otolaryngology in Africa.net - Journal Watch: Is endoscopy necessary in Globus pharyngeus? Watch out for otolaryngologyinafrica.net Journal Club Page! Till Next Week, Biodun

Text Box: This is a free email newsletter circulating to Otolaryngologists in Africa, and interested Otolaryngologists elsewhere. If you know anyone interested in receiving this free newsletter, feel free to forward a copy to such person or encourage them to email orl-mailer@otolaryngologyinafrica.net for subscription                                                      © Copyright Dr 'Biodun Olusesi,  2005 - 2006

 

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Case Review

Clinical Audiogram of The Week

An 46-year old male presented with  difficulty in hearing conversation speech of 12 years duration. He often resorted to carrying out 'Toynbee's maneuvre" - swallow against pinched nose, closed mouth in order to be able to hear in the right ear. He gave a history of unsuccessful ossiculoplasty both ears ten years previously. Examination revealed bilaterally normal EACs and Tympanic membranes. Tuning fork assessment revealed bilateral conductive hearing loss. Pure tone audiometry revealed the audiogram displayed here. You may click on the audiogram to view a larger picture of the audiogram