Text Box: Editor's Choice:    Migraine & New Surgical Approach ...? ) by the same worker who first reported transient pitch-perception deficit associated with carbamazepine in 1993 observed the same phenomenon in 6 more cases and concluded that auditory deficit might be an overlooked side effect of carbamazepin therapy  

Abstract:  This report presents six cases of transient auditory disturbance caused by carbamazepine, with a particular focus on pitch-perception deficit. Basic disorders in the six cases included epilepsy (cryptogenic localization–related epilepsy and benign childhood epilepsy) and glossopharyngeal neuralgia. Since 1993, in which we reported the first description of transient pitch-perception deficit associated with carbamazepine, a further 26 cases have been reported. However, this carbamazepine-induced transient pitch-perception deficit may be more frequent than previously suspected. Moreover, because auditory disturbance occurs at therapeutic serum levels of carbamazepine, patient awareness of reversible hearing impairment on initiating carbamazepine therapy is important.





  Text Box: Abreast of Ear, Nose, Throat, Head & Neck Advances

Text Box: August 15, 2006

Text Box: Otorhinolaryngology News

Text Box: Inside This Issue · LigMigraine & New surgery..? · Carbamazepin & Auditory Deficit? · TinMeniere's & Water intake..? *     Case of the Week

 

 

 Case Review

 Clinical Photograph of The Week

An 34-year old male presented with painless left sided angle of jaw swelling of 3 years duration. Examination revealed firm, rubbery mass felt at the area of lower lobe of the left parotid gland. CT-scan demonstrated a mass superficial to the angle of the mandible. The entire superficial parotid lobe was found to be normal at parotidectomy. At completion of superficial parotidectomy, the finding shown (blue arrows) in this picture was found deep to the buccal branch of facial nerve

 

    

What is the Diagnosis?

1. 110th American Academy of ORL, Head & Neck Surgery Annual Meeting & OTO EXPO, September 17-20, 2006; Toronto, Canada.

2.          42nd South African ENT Congress joint meeting with the British Association of Otolaryngology - Head & Neck Surgery, October 8 - 11, 2006; Cape Town, South Africa. Click HERE for More Info

3.         16th Annual oto-rhino-laryngological society of Nigeria (ORLSON) General Meeting & Scientific Conference; November 22nd - 25th, 2006; Kaduna, Nigeria
 
This thought-provoking study from Japan (Naganuma H. et al, Laryngoscope: Volume 116(8), August 2006, pp 1455-1460 ) observed that deliberate modulation of water intake may be the most cost-effective non-operative means of controlling vertigo in individuals with Meniere's disease.

Abstract: Objectives/Hypothesis: We examined whether sufficient water intake is effective in the long-term control of vertigo and hearing activity in patients with Meniere disease (MD) for whom conventional therapy has proven unsuccessful.

Study Design: The authors conducted a time-series study with historical control.

Methods: Eighteen patients with MD in group 1 drank 35 mL/kg per day of water for 2 years. Twenty-nine patients with MD treated with the conventional dietary and diuretic therapy for more than 2 years during 1992 to 1999 at the same hospital were enrolled in a historical control of group 2.

Results: Patients in group 1 dramatically relieved vertigo and significantly improved in the hearing of the worst pure-tone average of three frequencies (0.125, 0.25, and 0.5 kHz) (low PTA) during the last 6 months of the study period. In contrast, patients in group 2 became worse in both the four- (0.5, 1, 2, and 4 kHz) frequency PTA and the low PTA, although their vertigo did improve. The number of patients whose hearing were improved, unchanged, and worse were 4, 12, and 2 in group 1 and 2, 11, and 16 in group 2, respectively.

Conclusion: Deliberate modulation of the intake of water may be the simplest and most cost-effective medical treatment for patients with MD. Larger studies will be needed to confirm these results in a larger patient cohort.

 



 

     Journal Watch :Cyst and Congenital Fistula of The Neck ( In Congo) - Ondzoto G. et al 2005

 

  1.  Reviewers wanted for otolaryngology news journal's watch page. If you are an Otolaryngologist in Africa and will like to be our journal reviewer, please feel free to email orl-mailer@otolaryngologyinafrica.net

  2.   DODA 2006, capable of advanced hearing measure, and also paediatric hearing assessment is being developed. If you requested for and got a free copy of DODA, you may also look out for this latest version dubbed DODA-i, as well as for an additional page on outcome of hearing assessment using DODA.

 3.  A subweb of this site, dedicated to online publications of otorhinolaryngological grand round presentations across Institutions all over Africa will soon take off. The subweb once active can be accessed at http://www.otolaryngologyinafrica.net/grandround/ . Watch out, and please take advantage of this to send in your grand round presentations. Also watch out for online discussion forum for discussion of issues concerning otolaryngologists, but not really of clinical nature at http://otolaryngologyinafrica.net/discussionforum/ 

 Till Next Week,

 Biodun

 
 

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